Prostate
PSA
The prostate is a gland in the male reproductive system located
just below the bladder, in front of the rectum. About the size
and shape of a walnut, the prostate weighs only about one ounce.
The prostate wraps around the urethra, a tube that carried urine
from the bladder and out through the penis. The main purpose of
the prostate is to produce semen, which is squeezed out through
the prostate during orgasm. The prostate gland works in conjunction
with the male urethra. The urethra is responsible for carrying
urine from the bladder to the tip of the penis during urination
as well as carrying semen during ejaculation. Part of the seminal
fluid that is ejaculated during orgasm is produced by the prostate
gland, while the remaining fluid is produced by two seminal vesicles.
Smooth muscle tissue is also present in the prostate gland which
serves to assist with expelling semen during ejaculation. Androgens,
also known as male hormones, help the prostate to function properly.
The main male hormone, testosterone, is produced by the testicles
and is critical to healthy prostate gland function.
Antigens are a type of substance that stimulates the production
of antibodies by the immune system and are found on the surface
of cells. While antigens are normal in the human body, cancer
cells release higher levels of antigens into the bloodstream,
than are normally present. The release of these antigens makes
it possible to detect cancer through blood tests.
Prostate PSA, also known as prostate-specific antigen is a protein
that is produced exclusively the prostate gland. A blood test
can be performed to determine the presence of prostate cancers
and is in fact one of the most effective ways to detect prostate
PSA. A high level of prostate PSA may not always indicate the
presence of prostate cancer, as high levels may also be present
in the case of other prostate disorders such as an inflamed or
enlarged prostate. A prostate PSA can be a good place to begin,
however when a patient is experiencing symptoms related to prostate
cancer.
Prostate cancer is one of the leading types of cancers diagnosed
in American men. Each year almost a quarter of a million new cases
are diagnosed. It is estimated that prostate cancer will affect
one out of every ten men. Each year more than 30,000 men die from
prostate cancer. Because of the seriousness of the problem, prostate
cancer is perhaps the most serious of all the different types
of prostate disease. Prostate cancer generally occurs in men who
are over the age of 65, although cases in younger men have been
reported. There is a high incidence of prostate cancer occurring
in men who are shown to have a family history of this type of
prostate disease. African-American men are considered to be particularly
at risk for prostate cancer and suffer from the highest death
rates related to this disease. Physicians now recommend that all
men over the age of 50 have a prostate disease and cancer screening
once a year and that men who are considered to be in high risk
groups, such as African-Americans, begin to have annual screenings
by age 45. Prostate cancer begins with a tumor growing on the
outside of the prostate. Prostate cancer can develop slowly over
a period of years and because it may not initially show any symptoms,
it may go unchecked until it has spread to other parts of the
body. One of the most serious concerns regarding the spread of
prostate cancer is the proximity of nearby lymph nodes which may
be compromised by the growing cancer. Symptoms of prostate cancer
can include changes in urination. Pain the lower back, upper pelvis,
legs and thighs is also considered to be a symptom of prostate
cancer. Men who fall into one of the high risk groups or who are
experiencing prostate cancer related symptoms should have a prostate
PSA performed.
The prostate PSA is a very simple procedure and only involves
minor blood work so there is no need for a hospital stay or even
for the use of anesthesia. Usually a prostate PSA can be performed
right in the doctor's office or in a lab. The prostate PSA is
conducted by taking a blood sample from the patient's arm. The
technician will then expose the blood sample to an antibody that
is known to attack prostate PSA and the amount of prostate PSA
present will then be measured. Normally, a prostate PSA range
is between 0-4 ng/mL. Older men, however; do tend to have higher
levels of prostate PSA. It is recommended that men who are at
least 50 years of age have an annual rectal exam as well as a
digital rectal exam.
If the physician feels what he or she believes to be an abnormality
during the exam, they may order a prostate PSA to make a determination
regarding the presence of prostate cancer. The presence of prostate
PSA does not always indicate prostate cancer. Sometimes the prostate
simply becomes inflamed due to bacteria that are present and this
can sometimes account for a raised prostate PSA level. In other
cases, the prostate may be enlarged which can contribute to symptoms
similar to prostate cancer as well as a raised prostate PSA level.
If the test if positive, the doctor will most likely need to perform
a biopsy in order to make a positive or negative prostate cancer
diagnosis. The biopsy is more invasive than the prostate PSA test
and comes with more risks, however; it is necessary to diagnose
the presence of prostate cancer. If the test turns out to be negative,
but there have been some prostate disorder related symptoms or
the doctor believes there was an abnormality felt during the rectal
exam, they may need to repeat the test. The test results can sometimes
be inconclusive if there was not enough blood drawn.
If a patient is diagnosed with prostate cancer, the prostate
PSA may also be used to monitor the prostate PSA levels of the
patient during treatment. |